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Article

Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch.

Nature communications - 13 Jun 2016

Xue Yi, Gracia Brant, Herschlag Daniel, Russell Rick, Al-Hashimi Hashim M

Abstract excerpt

Intermediates play important roles in RNA folding but can be difficult to characterize when short-lived or not significantly populated. By combining (15)N relaxation dispersion NMR with chemical probing, we visualized a fast (kex=k1+k-1≈423 s(-1)) secondary structural switch directed towards a low-populated (∼3%) partially folded intermediate in tertiary folding of the P5abc subdomain of the 'Tetrahymena' group I...

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Identifiers

PMID: 27292179
DOI: 10.1038/ncomms11768
PMCID: PMC4909931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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