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Article

Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization.

Journal of virology - 1 May 1997

Laughrea M, Jetté L, Mak J, Kleiman L, Liang C, Wainberg M A

Abstract excerpt

A stem-loop termed the kissing-loop hairpin is one of the most highly conserved structures within the leader of human immunodeficiency virus type 1 (HIV-1) and chimpanzee immunodeficiency virus genomic RNA. Because it plays a key role in the in vitro dimerization of short HIV-1 RNA transcripts (M. Laughrea and L. Jette, Biochemistry 35:1589-1598, 1996, and references therein; M. Laughrea and L. Jette,...

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Identifiers

PMID: 9094609
DOI: 10.1128/JVI.71.5.3397-3406.1997
PMCID: PMC191484

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