Article

Dimerization Mechanism of HIV-1 RNA Hairpins to Extended Duplex Structures

2025-10-22

Abstract excerpt

Genomic RNA (gRNA) dimerization is essential for retroviral replication. In the gRNA of human immunodeficiency virus (HIV-1), the hairpin-like dimerization initiation sequence (DIS) forms a kissing-complex (KC) with the DIS sequence in another gRNA, which later converts into a stable extended-duplex (ED). Using coarse-grained simulations, we mapped the transition of HIV-1 DIS RNA hairpins (HPs) to ED and identifie...

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Literature Corpus work: 7a706691-97c9-50e5-ad3c-f4eedd82f1f6
DOI: 10.1101/2025.10.22.683870

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