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Article

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Immunology and cell biology - 1 Jan 2000

Ma Cindy S, Suryani Santi, Avery Danielle T, Chan Anna, Nanan Ralph, Santner-Nanan Brigitte, Deenick Elissa K, Tangye Stuart G

Abstract excerpt

T follicular helper (T(FH)) cells are a specialized subset of CD4(+) T cells that localize to B-cell follicles, where they are positioned to provide help for the induction of optimal humoral immune responses. Key features of T(FH) cells are the expressions of CXCR5, ICOS, interleukin (IL)-21 and...

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Source

Identifiers

PMID: 19721453
DOI: 10.1038/icb.2009.64

Genes

CXCR5
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19721453-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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