Article
STAT3: an important regulator of multiple cytokine functions.
Transplantation - 27 May 2008
Stepkowski Stanislaw M, Chen Wenhao, Ross Jeremy A, Nagy Zsuzsanna S, Kirken Robert A
Abstract excerpt
Maintaining T cell homeostasis is critical for normal immune response. Three sequential signals activate T cells, with signal 3 delivered by multiple cytokines that regulate cell proliferation, differentiation, and survival/death. Cytokines binding to their receptors engages two key molecular families, namely, Janus tyrosine kinases (Jaks) and signal transducers and activators of transcription (Stats). Among...
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