STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.

doi:10.1084/jem.20141992

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Article

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function.

The Journal of experimental medicine - 1 Jun 2015

Wilson Robert P, Ives Megan L, Rao Geetha, Lau Anthony, Payne Kathryn, Kobayashi Masao, Arkwright Peter D, Peake Jane, Wong Melanie, Adelstein Stephen, Smart Joanne M, French Martyn A, Fulcher David A, Picard Capucine, Bustamante Jacinta, Boisson-Dupuis Stephanie, Gray Paul, Stepensky Polina, Warnatz Klaus, Freeman Alexandra F, Rossjohn Jamie, McCluskey James, Holland Steven M, Casanova Jean-Laurent, Uzel Gulbu, Ma Cindy S, Tangye Stuart G, Deenick Elissa K

Abstract excerpt

Unconventional T cells such as γδ T cells, natural killer T cells (NKT cells) and mucosal-associated invariant T cells (MAIT cells) are a major component of the immune system; however, the cytokine signaling pathways that control their development and function in humans are unknown. Primary immunodeficiencies caused by single gene mutations provide a unique opportunity to investigate the role of specific...

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PMID: 25941256
DOI: 10.1084/jem.20141992
PMCID: PMC4451129

Genes

STAT3
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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