Article
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells.
The Journal of experimental medicine - 7 Jul 2008
de Beaucoudrey Ludovic, Puel Anne, Filipe-Santos Orchidée, Cobat Aurélie, Ghandil Pegah, Chrabieh Maya, Feinberg Jacqueline, von Bernuth Horst, Samarina Arina, Jannière Lucile, Fieschi Claire, Stéphan Jean-Louis, Boileau Catherine, Lyonnet Stanislas, Jondeau Guillaume, Cormier-Daire Valérie, Le Merrer Martine, Hoarau Cyrille, Lebranchu Yvon, Lortholary Olivier, Chandesris Marie-Olivia, Tron François, Gambineri Eleonora, Bianchi Lucia, Rodriguez-Gallego Carlos, Zitnik Simona E, Vasconcelos Julia, Guedes Margarida, Vitor Artur Bonito, Marodi Laszlo, Chapel Helen, Reid Brenda, Roifman Chaim, Nadal David, Reichenbach Janine, Caragol Isabel, Garty Ben-Zion, Dogu Figen, Camcioglu Yildiz, Gülle Sanyie, Sanal Ozden, Fischer Alain, Abel Laurent, Stockinger Birgitta, Picard Capucine, Casanova Jean-Laurent
Abstract excerpt
The cytokines controlling the development of human interleukin (IL) 17--producing T helper cells in vitro have been difficult to identify. We addressed the question of the development of human IL-17--producing T helper cells in vivo by quantifying the production and secretion of IL-17 by fresh T cells ex vivo, and by T cell blasts expanded in vitro from patients with particular genetic traits affecting...
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