Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic instrument for Mendelian randomization of fibrinogen.

European journal of epidemiology - 1 Apr 2012

Ken-Dror Gie, Humphries Steve E, Kumari Meena, Kivimaki Mika, Drenos Fotios

Abstract excerpt

Mendelian randomization studies on fibrinogen commonly use a single genetic variant as an instrument, but this may explain only a small proportion of the total phenotypic variance. We examined the contribution of multiple common single nucleotide polymorphisms (SNPs) and haplotypes in the entire fibrinogen gene cluster to plasma fibrinogen levels in two prospective cohorts, for use as instruments in future...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Coronary Disease
Share to Fibrinogen
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Mendelian Randomization Analysis

Share to Multigene Family

Share to Survival Analysis

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 22388766
DOI: 10.1007/s10654-012-9666-x
PMCID: PMC4181528

Genes

FGA
FGB
FGG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic instrument for Mendelian randomization of fibrinogen.PMID 22388766Read ↗

Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations.Semantic proximity Read ↗

Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.Semantic proximity Read ↗

Mendelian Randomization evaluation of causal effects of fibrinogen on incident coronary heart diseaseSemantic proximity Read ↗

Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study.Semantic proximity Read ↗

Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke.Semantic proximity Read ↗

A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke.Semantic proximity Read ↗

A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study.Semantic proximity Read ↗

Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.Semantic proximity Read ↗

Candidate gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation.Semantic proximity Read ↗

Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.Semantic proximity Read ↗

Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.