Article
A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke.
Blood - 24 Dec 2020
Maners Jillian, Gill Dipender, Pankratz Nathan, Laffan Michael A, Wolberg Alisa S, de Maat Moniek P M, Ligthart Symen, Tang Weihong, Ward-Caviness Cavin K, Fornage Myriam, Debette Stephanie, Dichgans Martin, McKnight Barbara, Boerwinkle Eric, Smith Nicholas L, Morrison Alanna C, Dehghan Abbas, de Vries Paul S
Abstract excerpt
Fibrinogen is a key component of the coagulation cascade, and variation in its circulating levels may contribute to thrombotic diseases, such as venous thromboembolism (VTE) and ischemic stroke. Gamma prime (γ') fibrinogen is an isoform of fibrinogen that has anticoagulant properties. We applied 2-sample Mendelian randomization (MR) to estimate the causal effect of total circulating fibrinogen and its isoform, γ'...
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