Article
Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2006
Reiner A P, Carty C L, Carlson C S, Wan J Y, Rieder M J, Smith J D, Rice K, Fornage M, Jaquish C E, Williams O D, Tracy R P, Lewis C E, Siscovick D S, Boerwinkle E, Nickerson D A
Abstract excerpt
BACKGROUND: Previous genotype-phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and between major ethnic groups in FGB, FGA, and FGG. METHODS: We characterized the linkage disequilibrium patterns and haplotype structure across the human fibrinogen gene locus in European- and African-American populations. We analyzed the association between...
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