Article
Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke.
Journal of thrombosis and haemostasis : JTH - 1 Mar 2009
Siegerink B, Rosendaal F R, Algra A
Abstract excerpt
BACKGROUND: Confounding by common causes and reverse causation have been proposed as explanations for the association between high fibrinogen levels and cardiovascular disease. Genetic variants can alter fibrinogen characteristics and are not subject to these problems. OBJECTIVES: To determine the fibrinogen plasma levels for genotypic variants in fibrinogen-A alpha (FGA Thr312Ala) and fibrinogen-B beta (FGB -...
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