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Article

Candidate gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jul 2017

Cronjé H Toinét, Nienaber-Rousseau Cornelie, Zandberg Lizelle, Chikowore Tinashe, de Lange Zelda, van Zyl Tertia, Pieters Marlien

Abstract excerpt

Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted...

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Source

Identifiers

PMID: 27771416
DOI: 10.1016/j.matbio.2016.10.005

Genes

CRP
CBS
FGA
FGB
FGG
APOB
APOE
MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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