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Article

Genetic polymorphisms of the TYMS gene are not associated with congenital cardiac septal defects in a Han Chinese population.

PloS one - 1 Jan 2012

Zhao Jian-Yuan, Sun Jing-Wei, Gu Zhuo-Ya, Wang Jue, Wang Er-Li, Yang Xue-Yan, Qiao Bin, Duan Wen-Yuan, Huang Guo-Ying, Wang Hong-Yan

Abstract excerpt

BACKGROUND: Clinical research indicates that periconceptional administration of folic acid can reduce the occurrence of congenital cardiac septal defects (CCSDs). The vital roles of folate exhibits in three ways: the unique methyl donor for DNA expression regulation, the de novo biosynthesis of p...

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Identifiers

PMID: 22384047
DOI: 10.1371/journal.pone.0031644
PMCID: PMC3285645

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22384047-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Genetic polymorphisms of the TYMS gene are not associated with congenital cardiac septal defects in a Han Chinese population.PMID 22384047Read ↗

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).Semantic proximity Read ↗

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Thymidylate synthase polymorphisms and risk of conotruncal heart defects.Semantic proximity Read ↗

Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.Semantic proximity Read ↗

Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese populationSemantic proximity Read ↗

NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.Semantic proximity Read ↗

Distribution of the most common polymorphisms in TYMS gene in Slavic population of central Europe.Semantic proximity Read ↗

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.Semantic proximity Read ↗

Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect.Semantic proximity Read ↗

High Frequency of Low Expression Genotypes in Mexican Population for the TYMS Gene Predicted From the TSER and G>C VariantsSemantic proximity Read ↗

A genetic variant in a homocysteine metabolic gene that increases the risk of congenital cardiac septal defects in Han Chinese populations.Semantic proximity Read ↗

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