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Article

Genetic polymorphisms of the TYMS gene are not associated with congenital cardiac septal defects in a Han Chinese population.

PloS one - 1 Jan 2012

Zhao Jian-Yuan, Sun Jing-Wei, Gu Zhuo-Ya, Wang Jue, Wang Er-Li, Yang Xue-Yan, Qiao Bin, Duan Wen-Yuan, Huang Guo-Ying, Wang Hong-Yan

Abstract excerpt

BACKGROUND: Clinical research indicates that periconceptional administration of folic acid can reduce the occurrence of congenital cardiac septal defects (CCSDs). The vital roles of folate exhibits in three ways: the unique methyl donor for DNA expression regulation, the de novo biosynthesis of purine and pyrimidine for DNA construction, and the serum homocysteine removal. Thymidylate synthase (TYMS) is the solo...

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Identifiers

PMID: 22384047
DOI: 10.1371/journal.pone.0031644
PMCID: PMC3285645

Genes

TYMS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms of the TYMS gene are not associated with congenital cardiac septal defects in a Han Chinese population.PMID 22384047Read ↗

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