Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.

Genes - 9 Jan 2023

Webber Daniel M, Li Ming, MacLeod Stewart L, Tang Xinyu, Levy Joseph W, Karim Mohammad A, Erickson Stephen W, Hobbs Charlotte A, The National Birth Defects Prevention Study

Abstract excerpt

Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality. Evidence from epidemiological studies suggests that maternal folate intake is associated with a reduced risk of heart defects, including CTD. However, it is unclear if folate-related gene variants and maternal folate intake have an interactive effect on the risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fetus
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Heart Defects, Congenital

Source

Open in PubMed Open full text

Identifiers

PMID: 36672920
DOI: 10.3390/genes14010180
PMCID: PMC9859210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.PMID 36672920Read ↗

Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.Semantic proximity Read ↗

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.Semantic proximity Read ↗

The impact of nationwide folic acid fortification on genetic variants associated with conotruncal heart defectsSemantic proximity Read ↗

Variants of folate metabolism genes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Gene-by-gene interactions associated with the risk of conotruncal heart defects.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.Semantic proximity Read ↗

Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.Semantic proximity Read ↗

The A1298C Methylenetetrahydrofolate Reductase Gene Variant as a Susceptibility Gene for Non-Syndromic Conotruncal Heart Defects in an Indian Population.Semantic proximity Read ↗

Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart DiseaseSemantic proximity Read ↗

A parent-of-origin analysis of paternal genetic variants and increased risk of conotruncal heart defects.Semantic proximity Read ↗

Thymidylate synthase polymorphisms and risk of conotruncal heart defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.