Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thymidylate synthase polymorphisms and risk of conotruncal heart defects.

American journal of medical genetics. Part A - 1 Sept 2012

Zhu Huiping, Yang Wei, Shaw Nathan, Perloff Spencer, Carmichael Suzan L, Finnell Richard H, Shaw Gary M, Lammer Edward J

Abstract excerpt

In this study, we investigated whether the two TYMS functional variants (28 bp VNTR and 1494del6) (275 cases and 653 controls) and six selected SNPs (265 case infants, 535 control infants; 169 case mothers and 276 control mothers) were associated with risks of conotruncal heart defects. Further, we evaluated interaction effects between these gene variants and maternal folate intake for risk of CTD. Cases with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Heart Defects, Congenital

Share to Infant, Newborn

Share to Polymerase Chain Reaction

Share to Risk Factors

Share to Thymidylate Synthase

Source

Open in PubMed Open full text

Identifiers

PMID: 22887475
DOI: 10.1002/ajmg.a.35310
PMCID: PMC3429723

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase polymorphisms and risk of conotruncal heart defects.PMID 22887475Read ↗

Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.Semantic proximity Read ↗

NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.Semantic proximity Read ↗

Gene-by-gene interactions associated with the risk of conotruncal heart defects.Semantic proximity Read ↗

Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.Semantic proximity Read ↗

The A1298C Methylenetetrahydrofolate Reductase Gene Variant as a Susceptibility Gene for Non-Syndromic Conotruncal Heart Defects in an Indian Population.Semantic proximity Read ↗

Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes.Semantic proximity Read ↗

Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.Semantic proximity Read ↗

A parent-of-origin analysis of paternal genetic variants and increased risk of conotruncal heart defects.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.Semantic proximity Read ↗

Variants of folate metabolism genes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Gene variants in the folate-mediated one-carbon metabolism (FOCM) pathway as risk factors for conotruncal heart defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.