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Article

NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2011

Lupo Philip J, Mitchell Laura E, Goldmuntz Elizabeth

Abstract excerpt

BACKGROUND: Although congenital heart defects (CHDs) are a common and serious group of birth defects, relatively little is known about the causes of these conditions, and there are no established prevention strategies. There is, however, evidence suggesting that the risk of CHDs in general, and conotruncal and related defects (CTRDs) in particular, may be associated with maternal folate status and genetic...

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Topics

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Share to Arylamine N-Acetyltransferase
Share to Folic Acid
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Nitric Oxide Synthase Type III

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Thymidylate Synthase

Source

Open in PubMed Open full text

Identifiers

PMID: 21254360
DOI: 10.1002/bdra.20745
PMCID: PMC4404296

Genes

NOS3
TYMS
NAT1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.PMID 21254360Read ↗

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Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.Semantic proximity Read ↗

Thymidylate synthase polymorphisms and risk of conotruncal heart defects.Semantic proximity Read ↗

Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects.Semantic proximity Read ↗

The A1298C Methylenetetrahydrofolate Reductase Gene Variant as a Susceptibility Gene for Non-Syndromic Conotruncal Heart Defects in an Indian Population.Semantic proximity Read ↗

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.Semantic proximity Read ↗

Variants of folate metabolism genes and risk of left-sided cardiac defects.Semantic proximity Read ↗

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