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Article

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.

BMC cancer - 25 May 2006

Zhai Xiangjun, Gao Jun, Hu Zhibin, Tang Jinhai, Qin Jianwei, Wang Shui, Wang Xuechen, Jin Guangfu, Liu Jiyong, Chen Wenshen, Chen Feng, Wang Xinru, Wei Qingyi, Shen Hongbing

Abstract excerpt

BACKGROUND: Accumulative evidence suggests that low folate intake is associated with increased risk of breast cancer. Polymorphisms in genes involved in folate metabolism may influence DNA methylation, nucleotide synthesis, and thus individual susceptibility to cancer. Thymidylate synthase (TYMS) is a key enzyme that participates in folate metabolism and catalyzes the conversion of dUMP to dTMP in the process of...

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PMID: 16723031
DOI: 10.1186/1471-2407-6-138
PMCID: PMC1539016

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TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.PMID 16723031Read ↗

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A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations.Semantic proximity Read ↗

Thymidylate synthase genetic polymorphisms and cancer risk: a meta-analysis of 37 case-control studies.Semantic proximity Read ↗

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