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Article

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.

Birth defects research. Part A, Clinical and molecular teratology - 1 Feb 2014

Hobbs Charlotte A, Cleves Mario A, Macleod Stewart L, Erickson Stephen W, Tang Xinyu, Li Jingyun, Li Ming, Nick Todd, Malik Sadia

Abstract excerpt

BACKGROUND: We investigated the association between conotruncal heart defects (CTDs) and maternal and fetal single nucleotide polymorphisms (SNPs) in 60 genes in the folate, homocysteine, and transsulfuration pathways. We also investigated whether periconceptional maternal folic acid supplementation modified associations between CTDs and SNPs METHODS: Participants were enrolled in the National Birth Defects...

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PMID: 24535845
DOI: 10.1002/bdra.23225
PMCID: PMC4118819

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GCLC
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