Article
A genetic variant in a homocysteine metabolic gene that increases the risk of congenital cardiac septal defects in Han Chinese populations.
IUBMB life - 1 Sept 2017
Xie Han-Hui, Li Jiong, Li Pei-Qiang, Zhang An-An, Li Yi, Wang Yan-Zhen, Xie Ding-Xiong, Xie Xiao-Dong
Abstract excerpt
Elevated homocysteine levels are known to be a risk factor for congenital cardiac septal defects (CCSDs), but the mechanism underlying this effect is unknown. The genetic variants that were significantly associated with circulating homocysteine concentrations have been systematically identified through the genome-wide association studies of one-carbon core metabolites. To examine the role of the genome-wide...
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