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Article

Distribution of the most common polymorphisms in TYMS gene in Slavic population of central Europe.

Neoplasma - 1 Jan 2000

Pastorakova A, Chandogova D, Chandoga J, Luha J, Bohmer D, Malova J, Braxatorisova T, Juhosova M, Reznakova S, Petrovic R

Abstract excerpt

Thymidylate synthetase (TS) plays a critical role in the de novo synthesis of dTMP inside the cell. Therefore, TS is a suitable target for cytotoxic drugs such as fluoropyrimidines. Drug efficacy and toxicity depend on the intracellular level of TS, which is significantly influenced by the polymorphisms in the 5'UTR (TSER - rs45445694, TSER*3G>C - rs2853542) and 3'UTR (1494del TTAAAG - rs151264360) of TYMS gene....

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Identifiers

PMID: 28895423
DOI: 10.4149/neo_2017_620

Genes

TYMS

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