Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).

Drug metabolism and pharmacokinetics - 1 Dec 2006

Kim Su-Ryang, Ozawa Shogo, Saito Yoshiro, Kurose Kouichi, Kaniwa Nahoko, Kamatani Naoyuki, Hamaguchi Tetsuya, Shirao Kuniaki, Muto Manabu, Ohtsu Atsushi, Yoshida Teruhiko, Matsumura Yasuhiro, Saijo Nagahiro, Sawada Jun-ichi

Abstract excerpt

Forty genetic variations including 14 novel ones were found in the human TYMS gene, which encodes thymidylate synthase, in 263 Japanese cancer patients who received 5-fluorouracil (FU)-based chemotherapy. Three novel variations were located within the 28-bp tandem repeat sequence in the 5'-untranslated region (UTR) and were designated 5Rc, 3Rc-ins and 4Rc. Allele frequencies were 0.021 for 5Rc, 0.006 for 3Rc-ins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

Share to Introns

Share to Linkage Disequilibrium

Share to Tandem Repeat Sequences

Share to Thymidylate Synthase

Source

Identifiers

PMID: 17220568
DOI: 10.2133/dmpk.21.509

Genes

TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).PMID 17220568Read ↗

A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele.Semantic proximity Read ↗

Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis.Semantic proximity Read ↗

Identification of a novel single nucleotide polymorphism in the first tandem repeat sequence of the thymidylate synthase 2R allele.Semantic proximity Read ↗

Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.Semantic proximity Read ↗

Association between polymorphic sites in thymidylate synthase gene and risk of non-Hodgkin lymphoma: a systematic review and pooled analysis.Semantic proximity Read ↗

Distribution of the most common polymorphisms in TYMS gene in Slavic population of central Europe.Semantic proximity Read ↗

Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample.Semantic proximity Read ↗

Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients.Semantic proximity Read ↗

Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.Semantic proximity Read ↗

Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma.Semantic proximity Read ↗

Thymidylate synthase enhancer region: Novel allele in Indians.Semantic proximity Read ↗

Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.