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Article

Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.

BMC pediatrics - 30 Aug 2018

Wang Xike, Wei Haitao, Tian Ying, Wu Yue, Luo Lei

Abstract excerpt

BACKGROUND: Conotruncal heart defects (CTDs) are a subgroup of congenital heart defects that are considered to be the most common type of birth defect worldwide. Genetic disturbances in folate metabolism may increase the risk of CTDs. METHODS: We evaluated five single-nucleotide polymorphisms (SNPs) in genes related to folic acid metabolism: methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), solute...

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Topics

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Share to Reduced Folate Carrier Protein
Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

Share to Heart Defects, Congenital

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

Open in PubMed Open full text

Identifiers

PMID: 30165839
DOI: 10.1186/s12887-018-1266-9
PMCID: PMC6117882

Genes

MTHFR
MTRR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.PMID 30165839Read ↗

Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.Semantic proximity Read ↗

The A1298C Methylenetetrahydrofolate Reductase Gene Variant as a Susceptibility Gene for Non-Syndromic Conotruncal Heart Defects in an Indian Population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects.Semantic proximity Read ↗

Variants of folate metabolism genes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.Semantic proximity Read ↗

Conotruncal heart defects and common variants in maternal and fetal genes in folate, homocysteine, and transsulfuration pathways.Semantic proximity Read ↗

Association of MTHFR A1298C polymorphism with conotruncal heart disease.Semantic proximity Read ↗

Gene variants in the folate-mediated one-carbon metabolism (FOCM) pathway as risk factors for conotruncal heart defects.Semantic proximity Read ↗

Gene-by-gene interactions associated with the risk of conotruncal heart defects.Semantic proximity Read ↗

Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese populationSemantic proximity Read ↗

Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles.Semantic proximity Read ↗

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