Article
Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.
The Biochemical journal - 30 Sept 2020
Zheng Tongyin, Yang Yiran, Castañeda Carlos A
Abstract excerpt
Cells rely on protein homeostasis to maintain proper biological functions. Dysregulation of protein homeostasis contributes to the pathogenesis of many neurodegenerative diseases and cancers. Ubiquilins (UBQLNs) are versatile proteins that engage with many components of protein quality control (PQC) machinery in cells. Disease-linked mutations of UBQLNs are most commonly associated with amyotrophic lateral...
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