Article
Structural architecture of the human long non-coding RNA, steroid receptor RNA activator.
Nucleic acids research - 1 Jun 2012
Novikova Irina V, Hennelly Scott P, Sanbonmatsu Karissa Y
Abstract excerpt
While functional roles of several long non-coding RNAs (lncRNAs) have been determined, the molecular mechanisms are not well understood. Here, we report the first experimentally derived secondary structure of a human lncRNA, the steroid receptor RNA activator (SRA), 0.87 kB in size. The SRA RNA is a non-coding RNA that coactivates several human sex hormone receptors and is strongly associated with breast cancer....
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