Article
Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA).
Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002
Lanz Rainer B, Razani Bahram, Goldberg Aaron D, O'Malley Bert W
Abstract excerpt
Steroid receptor RNA activator (SRA) is an RNA transcript that functions as a eukaryotic transcriptional coactivator for steroid hormone receptors. We report here the isolation and functional characterization of distinct RNA substructures within the SRA molecule that constitute its coactivation function. We used comparative sequence analysis and free energy calculations to systematically study SRA RNA subdomains...
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