Article
Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nature communications - 7 Nov 2014
Hudson William H, Pickard Mark R, de Vera Ian Mitchelle S, Kuiper Emily G, Mourtada-Maarabouni Mirna, Conn Graeme L, Kojetin Douglas J, Williams Gwyn T, Ortlund Eric A
Abstract excerpt
The majority of the eukaryotic genome is transcribed, generating a significant number of long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent the most poorly understood product of transcription, recent work has shown lincRNAs fulfill important cellular functions. In addition to low sequence conservation, poor understanding of structural mechanisms driving lincRNA biology hinders systematic...
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