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A comprehensive structural and functional analysis of the ligand binding domain of the nuclear receptor superfamily reveals highly conserved signaling motifs and two distinct canonical forms through evolution

2020-01-02

Abstract excerpt

Nuclear receptors (NRs) are transcriptional factors that play an essential role in all aspects of human development, metabolism and physiology. A prime example of a NR is the glucocorticoid receptor (GR). Structure‑wise, the GR is typical of the NR superfamily, while its signaling is a part of multiple physiological mechanisms. In this study, using the GR and the steroid hormone receptors as a basis, an analysis o...

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Literature Corpus work
8cab3b74-4083-5897-9a85-b9f440323e39
DOI
10.3892/wasj.2020.30
Open publication

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A comprehensive structural and functional analysis of the ligand binding domain of the nuclear receptor superfamily reveals highly conserved signaling motifs and two distinct canonical forms through evolutionDOI 10.3892/wasj.2020.30
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