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Article

Alu RNA pseudoknot alterations influence SRP9/SRP14 association.

RNA (New York, N.Y.) - 16 Jul 2025

Gussakovsky Daniel, Brown Mira J F, Pereira Higor Sette, Meier Markus, Padilla-Meier G Pauline, Black Nicole A, Booy Evan P, Stetefeld Jörg, Patel Trushar R, McKenna Sean A

Abstract excerpt

There are over 1 million Alu elements in the human genome which can be transcribed into discrete, RNA polymerase III transcribed noncoding Alu RNAs. These Alu RNAs often interact with and are regulated by the protein heterodimer SRP9/SRP14. This interaction is dependent on a 5' pseudoknot domain in the Alu RNA that is thought to be held together by a canonical nucleotide triad within a U-turn motif. Herein, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40345827
DOI: 10.1261/rna.080359.124
PMCID: PMC12265939

Genes

SRP14
SRP9

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