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Article

Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype × testosterone interaction.

Psychoneuroendocrinology - 1 Jun 2012

Josephs Robert A, Telch Michael J, Hixon J Gregory, Evans Jacqueline J, Lee Hanjoo, Knopik Valerie S, McGeary John E, Hariri Ahmad R, Beevers Christopher G

Abstract excerpt

BACKGROUND: Striking parallels are observed when comparing the literature on the 5-HTTLPR of the serotonin transporter gene (SLC6A4) to the testosterone (T) literature on measures of stress reactivity and neural activity. Short (S) allele carriers and individuals higher in testosterone levels show exaggerated stress responses, amygdala hyperactivity, and reduction of amygdala-prefrontal cortex coupling when...

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Identifiers

PMID: 21978869
DOI: 10.1016/j.psyneuen.2011.09.006
PMCID: PMC3262096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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