Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus.

doi:10.1016/j.physbeh.2020.112876

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Article

Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus.

Physiology & behavior - 1 Jun 2020

Sun Xiaoqiang, Li Chuting, Zhong Xue, Dong Daifeng, Ming Qingsen, Gao Yidian, Xiong Ge, Cheng Chang, Zhao Haofei, Wang Xiang, Yao Shuqiao

Abstract excerpt

Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance...

Topics

Alleles
Brain
Genetic Loci
Genotype
Humans
Magnetic Resonance Imaging
Serotonin Plasma Membrane Transport Proteins
Stress, Psychological

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Identifiers

PMID: 32194071
DOI: 10.1016/j.physbeh.2020.112876

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