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Article

Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2012

Nalavadi Vijayalaxmi C, Muddashetty Ravi S, Gross Christina, Bassell Gary J

Abstract excerpt

Fragile X syndrome is caused by the loss of fragile X mental retardation protein (FMRP), which represses and reversibly regulates the translation of a subset of mRNAs in dendrites. Protein synthesis can be rapidly stimulated by mGluR-induced and protein phosphatase 2a (PP2A)-mediated dephosphorylation of FMRP, which is coupled to the dissociation of FMRP and target mRNAs from miRNA-induced silencing complexes....

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Identifiers

PMID: 22357842
DOI: 10.1523/JNEUROSCI.5057-11.2012
PMCID: PMC3427762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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