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Article

FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Dec 2007

Narayanan Usha, Nalavadi Vijayalaxmi, Nakamoto Mika, Pallas David C, Ceman Stephanie, Bassell Gary J, Warren Stephen T

Abstract excerpt

Fragile X syndrome is a common form of inherited mental retardation and is caused by loss of fragile X mental retardation protein (FMRP), a selective RNA-binding protein that influences the translation of target messages. Here, we identify protein phosphatase 2A (PP2A) as an FMRP phosphatase and report rapid FMRP dephosphorylation after immediate group I metabotropic glutamate receptor (mGluR) stimulation (<1...

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Identifiers

PMID: 18160642
DOI: 10.1523/JNEUROSCI.2969-07.2007
PMCID: PMC6673448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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