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Synaptic synthesis of the fragile X protein: Possible involvement in synapse maturation and elimination

2 Apr 1999

Abstract excerpt

Fragile X mental retardation syndrome results from the absence of or a defect in the protein (FMRP) encoded by the FMR1 gene. FMRP is found in dendrites and synapses as well as in the neuronal cell soma and nucleus, and although it is known to bind to RNA, the function of the protein in neurons is not known. We have studied activity-dependent changes in postsynaptically localized protein translation in central...

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Identifiers

PMID: 10208156
DOI: 10.1002/(sici)1096-8628(19990402)83:4<248::aid-ajmg3>3.0.co;2-1

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