Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.

Science signaling - 5 Feb 2008

Ronesi Jennifer A, Huber Kimberly M

Abstract excerpt

Fragile X syndrome (FXS) mental retardation is caused by loss-of-function mutations in an RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in patients or animal models of FXS have identified alterations in dendritic spine structure, as well as synaptic plasticity induced by metabotropic glutamate receptors (mGluRs). The translation of multiple messenger RNA (mRNA) targets of FMRP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Fragile X Mental Retardation Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Syndrome

Share to Mutation

Share to Neuronal Plasticity

Share to Receptors, Metabotropic Glutamate

Share to RNA, Messenger

Share to Synapses

Source

Identifiers

PMID: 18272470
DOI: 10.1126/stke.15pe6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.PMID 18272470Read ↗

Synaptic synthesis of the fragile X protein: Possible involvement in synapse maturation and eliminationSemantic proximity Read ↗

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.Semantic proximity Read ↗

Altered synaptic plasticity in a mouse model of fragile X mental retardation.Semantic proximity Read ↗

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndromeSemantic proximity Read ↗

Fragile X mental retardation protein: past, present and future.Semantic proximity Read ↗

Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat modelsSemantic proximity Read ↗

Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.Semantic proximity Read ↗

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.Semantic proximity Read ↗

The pathophysiology of fragile x syndrome.Semantic proximity Read ↗

Function of FMRP domains in regulating distinct roles of neuronal protein synthesisSemantic proximity Read ↗

Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.Semantic proximity Read ↗

Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.