Article
Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2015
Tang Bin, Wang Tingting, Wan Huida, Han Li, Qin Xiaoyan, Zhang Yaoyang, Wang Jian, Yu Chunlei, Berton Fulvia, Francesconi Walter, Yates John R, Vanderklish Peter W, Liao Lujian
Abstract excerpt
Fragile X syndrome (FXS) is an X-linked neurodevelopmental disorder characterized by severe intellectual disability and other symptoms including autism. Although caused by the silencing of a single gene, Fmr1 (fragile X mental retardation 1), the complexity of FXS pathogenesis is amplified because the encoded protein, FMRP, regulates the activity-dependent translation of numerous mRNAs. Although the mRNAs that...
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