Article
Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.
Nature communications - 22 Feb 2018
Khayachi Anouar, Gwizdek Carole, Poupon Gwénola, Alcor Damien, Chafai Magda, Cassé Frédéric, Maurin Thomas, Prieto Marta, Folci Alessandra, De Graeve Fabienne, Castagnola Sara, Gautier Romain, Schorova Lenka, Loriol Céline, Pronot Marie, Besse Florence, Brau Frédéric, Deval Emmanuel, Bardoni Barbara, Martin Stéphane
Abstract excerpt
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and the best-studied monogenic cause of autism. FXS results from the functional absence of the fragile X mental retardation protein (FMRP) leading to abnormal pruning and consequently to synaptic communication defects. Here we show that FMRP is a substrate of the small ubiquitin-like modifier (SUMO) pathway in the brain and...
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