Article

m⁶A-dependent FMRP control of DGKκ translation underlies core Fragile X phenotypes

2026-01-21

Abstract excerpt

Fragile X syndrome (FXS), a leading inherited cause of intellectual developmental disorder and autism, results from loss of the RNA-binding protein FMRP. Loss of FMRP causes excessive neuronal protein synthesis contributing to widespread functional disturbances, yet the mechanisms linking FMRP to specific mRNA targets remain unclear. We show that FMRP promotes translation of the brain mRNA DGKκ by binding m⁶A-modi...

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Literature Corpus work: d139d2a7-b934-59eb-842c-ec3e2b40f0e1
DOI: 10.64898/2026.01.20.700356

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m⁶A-dependent FMRP control of DGKκ translation underlies core Fragile X phenotypesDOI 10.64898/2026.01.20.700356Read

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