Article

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

2023-09-09

Abstract excerpt

<h4>Summary</h4> Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function and plasticity. Dysregulated protein synthesis is a central effect of FMRP loss and to date direct translational modulation has not been leveraged in the treatment of FXS. Thus, we examined th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7981fb2-42bc-5609-872f-3501fed13458
DOI: 10.1101/2023.09.08.553269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndromeDOI 10.1101/2023.09.08.553269Read

Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.Semantic proximity Read

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.Semantic proximity Read

Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.Semantic proximity Read

Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndromeSemantic proximity Read

Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.Semantic proximity Read

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to AutismSemantic proximity Read

Synaptic synthesis of the fragile X protein: Possible involvement in synapse maturation and eliminationSemantic proximity Read

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.Semantic proximity Read

Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype.Semantic proximity Read

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.Semantic proximity Read

m⁶A-dependent FMRP control of DGKκ translation underlies core Fragile X phenotypesSemantic proximity Read

Fragile X syndrome.Semantic proximity Read