Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.

Neuron - 18 Oct 2012

Bhattacharya Aditi, Kaphzan Hanoch, Alvarez-Dieppa Amanda C, Murphy Jaclyn P, Pierre Philippe, Klann Eric

Abstract excerpt

Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream of the translation machinery. We sought to perturb p70 ribosomal S6 kinase 1 (S6K1), a key translation initiation and elongation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysics
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Stimulation

Share to Excitatory Postsynaptic Potentials

Share to Interpersonal Relations

Share to Recognition, Psychology

Share to Ribosomal Protein S6 Kinases, 70-kDa

Share to Rotarod Performance Test

Source

Open in PubMed Open full text

Identifiers

PMID: 23083736
DOI: 10.1016/j.neuron.2012.07.022
PMCID: PMC3479445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.PMID 23083736Read ↗

Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice.Semantic proximity Read ↗

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome miceSemantic proximity Read ↗

Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice.Semantic proximity Read ↗

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndromeSemantic proximity Read ↗

Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat modelsSemantic proximity Read ↗

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.Semantic proximity Read ↗

Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.Semantic proximity Read ↗

Cell type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behaviour in fragile X syndrome model miceSemantic proximity Read ↗

m⁶A-dependent FMRP control of DGKκ translation underlies core Fragile X phenotypesSemantic proximity Read ↗

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.Semantic proximity Read ↗

Single Cell Transcriptomics Reveals Dysregulated Cellular and Molecular Networks in a Fragile X Syndrome modelSemantic proximity Read ↗

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.