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Article

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin.

The Journal of pathology - 1 Mar 2010

Kim Yoo Ri, Oh Ji Eun, Kim Min Sung, Kang Mi Ran, Park Sang Wook, Han Ji Youn, Eom Hyeon Seok, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Nuclear factor erythroid-related factor 2 (NRF2) encodes a transcription factor that induces expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations have been found in lung and head/neck cancers that inactivate KEAP1-mediated degradation of NRF2. The aim of this s...

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Share to Carcinoma, Squamous Cell
Share to DNA Mutational Analysis
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 19967722
DOI: 10.1002/path.2653

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19967722-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin.PMID 19967722Read ↗

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Identification of a Novel Epithelial-mesenchymal Transition Gene Signature Regulated by KEAP1-NRF2 Pathway in Esophageal CarcinomaSemantic proximity Read ↗

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NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer.Semantic proximity Read ↗

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