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Article

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.

Epigenetics - 1 Jun 2011

Muscarella Lucia Anna, Parrella Paola, D'Alessandro Vito, la Torre Annamaria, Barbano Raffaela, Fontana Andrea, Tancredi Antonio, Guarnieri Vito, Balsamo Teresa, Coco Michelina, Copetti Massimiliano, Pellegrini Fabio, De Bonis Patrizia, Bisceglia Michele, Scaramuzzi Gerardo, Maiello Evaristo, Valori Vanna Maria, Merla Giuseppe, Vendemiale Gianluigi, Fazio Vito Michele

Abstract excerpt

The KEAP1/Nrf2 pathway is a master regulator of several redox-sensitive genes implicated in resistance of tumor cells against chemotherapeutic drugs. Recent data suggest that epigenetic mechanisms may play a pivotal role in the regulation of KEAP1 expression. We performed a comprehensive genetic and epigenetic analysis of the KEAP1 gene in 47 non-small cell lung cancer tissues and normal specimens. Promoter...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Intracellular Signaling Peptides and Proteins

Share to Kelch-Like ECH-Associated Protein 1

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Source

Identifiers

PMID: 21610322
DOI: 10.4161/epi.6.6.15773

Genes

KEAP1

Provenance

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Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.PMID 21610322Read ↗

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