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Article

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.

Gastroenterology - 1 Oct 2008

Shibata Tatsuhiro, Kokubu Akiko, Gotoh Masahiro, Ojima Hidenori, Ohta Tsutomu, Yamamoto Masayuki, Hirohashi Setsuo

Abstract excerpt

BACKGROUND & AIMS: Biliary tract cancer (BTC) is a highly malignant tumor, and identification of effective therapeutic targets to improve prognosis is urgently required. Oncogenic activation of survival genes is important for cancer cells to overcome oxidative stresses induced by their microenvironments that include chronic inflammation or exposure to anticancer drugs. We attempted to examine whether deregulation...

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Source

Identifiers

PMID: 18692501
DOI: 10.1053/j.gastro.2008.06.082

Genes

BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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