Article
Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong.
The British journal of dermatology - 1 Jul 2012
Chiu M L S, Hu M, Ng M H L, Yeung C K, Chan J C-Y, Chang M M, Cheng S H, Li L, Tomlinson B
Abstract excerpt
BACKGROUND: Allopurinol has been reported as a common cause of severe cutaneous adverse reactions (SCARs). Recent studies in various populations suggest that HLA-B*58:01 is a strong genetic marker for allopurinol-induced SCAR, especially in populations with a high frequency of HLA-B*58:01. OBJECTIVES: To confirm the association link between HLA-B*58:01 and hypersensitivity reactions attributed to allopurinol use...
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