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Allopurinol-induced severe cutaneous adverse reactions in Vietnamese: the role of HLA alleles and other risk factors.

Pharmacogenomics - 1 Apr 2022

Ha Pham Tran Thu, Tran Quang Binh, Chu Chi Hieu, Nga Do Thi Quynh, Nguyen Hoang Anh, Nguyen Dinh Van, Phung Thanh Huong

Abstract excerpt

Aim: To reveal the association of three class I HLA alleles, including HLA-A*33:03, HLA-B*58:01 and HLA-C*03:02, and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese patients. Methods: A case-control study on 100 allopurinol-induced SCARs patients, 183 tolerant controls and 810 population controls was performed. The HLA-A*33:03 and HLA-C*03:02 alleles were detected with the nested...

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PMID: 35187976
DOI: 10.2217/pgs-2021-0156

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