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Article

Real-world evidence of population differences in allopurinol-related severe cutaneous adverse reactions in East Asians: A population-based cohort study.

Clinical and translational science - 1 May 2021

Sato Tsugumichi, Cheng Ching-Lan, Park Heung-Woo, Kao Yang Yea-Huei, Yang Min-Suk, Fujita Mizuki, Kumagai Yuji, Tohkin Masahiro, Saito Yoshiro, Sai Kimie

Abstract excerpt

Allopurinol-related severe cutaneous adverse reactions (SCARs) are strongly associated with HLA-B*58:01, the allele frequency (AF) of which is largely different among East Asians. However, evidence of population differences in SCAR development and relevance of genetic and/or other risk factors in the real-world remain unelucidated. This study aimed to evaluate population differences in allopurinol-related SCAR...

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PMID: 33382928
DOI: 10.1111/cts.12964
PMCID: PMC8212744

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