Article
Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2012
Whalley Heather C, Sussmann Jessika E, Johnstone Mandy, Romaniuk Liana, Redpath Holly, Chakirova Goultchira, Mukherjee Prerona, Hall Jeremy, Johnstone Eve C, Lawrie Stephen M, McIntosh Andrew M
Abstract excerpt
Bipolar disorder and schizophrenia share a number of clinical features and genetic risk variants of small effect, suggesting overlapping pathogenic mechanisms. The effect of single genetic risk variants on brain function is likely to differ in people at high familial risk versus controls as these individuals have a higher overall genetic loading and are therefore closer to crossing a threshold of disease...
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