Article
Neural mechanisms of a genome-wide supported psychosis variant.
Science (New York, N.Y.) - 1 May 2009
Esslinger Christine, Walter Henrik, Kirsch Peter, Erk Susanne, Schnell Knut, Arnold Claudia, Haddad Leila, Mier Daniela, Opitz von Boberfeld Carola, Raab Kyeon, Witt Stephanie H, Rietschel Marcella, Cichon Sven, Meyer-Lindenberg Andreas
Abstract excerpt
Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology. Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706). We show, by using an imaging genetics approach, that healthy carriers of rs1344706 risk genotypes exhibit no changes in regional activity but pronounced gene...
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