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Article

No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder.

Genes, brain, and behavior - 1 Apr 2011

Prata D P, Mechelli A, Picchioni M, Fu C H Y, Kane F, Kalidindi S, McDonald C, Kravariti E, Toulopoulou T, Bramon E, Walshe M, Murray R, Collier D A, McGuire P K

Abstract excerpt

The Disrupted-in-Schizophrenia-1 (DISC1) gene has been implicated in both schizophrenia and bipolar disorder by linkage and genetic association studies. Altered prefrontal cortical function is a pathophysiological feature of both disorders, and we have recently shown that variation in DISC1 modul...

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Source

Identifiers

PMID: 21091867
DOI: 10.1111/j.1601-183X.2010.00665.x

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21091867-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder.PMID 21091867Read ↗

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Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia.Semantic proximity Read ↗

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia.Semantic proximity Read ↗

The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.Semantic proximity Read ↗

Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.Semantic proximity Read ↗

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Semantic proximity Read ↗

Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.Semantic proximity Read ↗

DISC1 gene and affective psychopathology: a combined structural and functional MRI study.Semantic proximity Read ↗

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.Semantic proximity Read ↗

The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects.Semantic proximity Read ↗

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DISC1 is associated with cortical thickness and neural efficiency.Semantic proximity Read ↗

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