Article
Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents.
Molecular psychiatry - 1 Sept 2011
Raznahan A, Lee Y, Long R, Greenstein D, Clasen L, Addington A, Rapoport J L, Giedd J N
Abstract excerpt
Disrupted-in-schizophrenia-1 (DISC1), contains two common non-synonymous single-nucleotide polymorphisms (SNPs)--Leu607Phe and Ser704Cys--that modulate (i) facets of DISC1 molecular functioning important for cortical development, (ii) fronto-temporal cortical anatomy in adults and (iii) risk for diverse psychiatric phenotypes that often emerge during childhood and adolescence, and are associated with altered...
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