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Article

Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson’s disease

6 Feb 2012

Abstract excerpt

BACKGROUND AND PURPOSE: The preferential degeneration of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta is the pathological hallmark in Parkinson's disease (PD). The transcription factors NURR1 and PITX3 have been shown to play a crucial role in the maturation and survival of mDA neurons, and both of them were potential susceptibility genes for PD. METHODS: To determine whether NURR1...

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PMID: 22309633
DOI: 10.1111/j.1468-1331.2011.03644.x

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